A slight twist with the fingers.
A pimple.
A small decorative embellishment.
A small musical flourish.
A tilde.
A drawn line that is curvy or twisted.
A tiny bit
A tizzy
To wiggle, fidget or play with; to move around.
She sat and nervously twiddled her hair while she waited.
To flip or switch two adjacent bits (binary digits).
To be in an equivalence relation with.
To play with anything; hence, to be busy about trifles.