An obstacle, delay, disadvantage, blow (an adverse event which retards or prevents progress towards a desired outcome)
After some initial setbacks, the expedition went safely on its way.
The required distance between a structure and a road.
A step-like recession in a wall.
Setbacks were initially used for structural reasons, but now are often mandated by land use codes.
An offset to the temperature setting of a thermostat to cover a period when more or less heating is required than usual.
(possibly obsolete) A backset; a countercurrent; an eddy.
A backset; a check; a repulse; a relapse.