Someone with an untidy appearance.
That candidate will never get the job: he's a right scruff.
Stubble, facial hair (on males).
Crust.
Scurf.
The loose skin at the back of the neck of some animals.
The back of the neck, nape; also scruff of the neck.
He grabbed his unruly kid by the scruff of the neck, and took him home.
To lift or carry by the scruff.