Someone with exceptional skills in a certain field.
She sure was a hotshot on the keyboard, 93 words per minute!
A type of firefighter highly skilled in wildfire firefighting without external support, using basic tools that are backpacked in and manhandled about.
A fast freight train.
A dose of recreational drugs deliberately laced with poison.
To give (somebody) a dose of recreational drugs deliberately laced with poison.
Highly skilled.
He was a hotshot lawyer, with an astounding win-loss record.
Displaying talent.
Keep up those hotshot baskets, the scouts are sure to take notice.