The point of complete depletion, of the state of being used up.
We worked the mine to exhaustion, there's nothing left to extract.
Supreme tiredness; having exhausted energy.
I ran in the marathon to exhaustion, then I collapsed and had to be carried away.
The removal (by percolation etc) of an active medicinal constituent from plant material.
The removal of all air from a vessel (the creation of a vacuum).
An exhaustive procedure