To make someone a cripple; to cause someone to become physically impaired
The car bomb crippled five passers-by.
To damage seriously; to destroy
My ambitions were crippled by a lack of money.
To release a product (especially a computer program) with reduced functionality, in some cases, making the item essentially worthless.
The word processor was released in a crippled demonstration version that did not allow you to save.
To nerf something which is overpowered
(usually offensive) Having a less than fully functional limb, or injuries which prevent full mobility.
(usually offensive) Having any difficulty or impediment which can be likened to a crippling injury.