A chaotic situation where everything seems to go wrong. It is often caused by incompetence, communication failure, or a complex environment.
2013: Barbara Kruger: What a ridiculous clusterfuck of totally uncool jokers. I make my work about this kind of sadly foolish farce. I’m waiting for all of them to sue me for copyright infringement in response to the Supreme v Married To The Mob battle
To fuck (something) up, to make a total mess of.